The Association of Primary Aldosteronism With Glaucoma-related Fundus Abnormalities


The study compared 272 eyes from 137 PA patients and 352 eyes from 177 control subjects selected randomly from 1173 participants of a public glaucoma screening. The presence of glaucomatous optic disc appearance (rim thinning and cup enlargement) and retinal nerve fiber layer defects (RNFLDs) was determined independently from fundus photographs. The results were compared between the PA and control groups. Although the prevalence of glaucomatous optic disc appearance did not differ between the two groups, RNFLDs were more frequent in PA patients than in the control group. Moreover, RNFLDs with their central ends located around retinal vessels were characteristic of PA patients.

Authors: Yoshimi Ohshima, Tomomi Higashide, Kimikazu Sakaguchi, Makoto Sasaki, Sachiko Udagawa, Shinji Ohkubo, Takashi Yoneda, Kazuhisa Sugiyama
Keywords: fundus oculi, glaucoma
DOI Number: 10.1371/journal.pone.0242090      Publication Year: 2020

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