Clinical Studies

Clinical studies are the cornerstone of medical knowledge. By taking part in clinical research, patients get the opportunity to improve their own health while impacting the care of others.

The Primary Aldosteronism Foundation fosters research worldwide, and encourages everyone in the PA patient community to participate in clinical research. Below is the list of all clinical studies referenced by ClinicalTrials.gov under primary aldosteronism. The list includes all published studies and is updated as soon as they are made public. Click on the title of any study to be taken to a web page with full details on the US National Library of Medicine website.

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CXCR4 Targeted PET Imaging in APA Preoperative Localization Diagnosis

Summary:

The goal of this clinical trial is to evaluate the effectiveness of CXCR4 targeted PET imaging in preoperative localization diagnosis of primary aldosteronism (PA). Participants diagnosed with PA will be asked to be scanned by 68Ga-PentixaFor PET, and then underwent adrenal venous sampling (AVS). Then, the responsible adrenal adenoma will be resected by adrenalectomy, and examined with pathological section and staining. Researchers will compare the sensitivity and specificity between 68Ga-PentixaFor PET imaging and AVS in preoperative localization diagnosis of PA.

Status: Recruiting Trial Number: NCT05839483
Conditions: Primary aldosteronism
Interventions: Diagnostic Test: CXCR4
Locations: Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China

Real-time Monitoring of Cortisol - Comparison of Cortisol Levels in Four Biological Fluids (SensoCort)

Summary:

Cortisol is an essential for life hormone secreted in a pulsatile pattern on a diurnal rhythm. Given the complexity of cortisol secretion on a circadian rhythm with pulsations, current methods of cortisol measurement have limitations. Therefore, a non-invasive and ambulatory method would be useful to measure cortisol levels in real-time.

Status: Recruiting Trial Number: NCT06008184
Conditions: Adrenal Insufficiency, Cushing Syndrome, Hyperaldosteronism
Interventions: Other: 24 hours sampling of 4 biological fluids (blood, ISF, sweat and saliva); Other: 24 hours sampling of ISF or sweat (after validating the correlation with blood)
Locations: Vaudois University Central Hospital (CHUV), Lausanne, Vaud, Switzerland

Prevalence of Primary Aldosteronism in Atrial Fibrillation (ERETRIA)

Summary:

This is an observational prospective cross-sectional study, investigating the prevalence of primary aldosteronism in patients with atrial fibrillation.

Status: Recruiting Trial Number: NCT05973604
Conditions: Atrial Fibrilation, Primary aldosteronism
Interventions: Diagnostic Test: Screening and Confirmatory diagnostic test for primary aldosteronism
Locations: Ippokratio General Hospital, Thessaloniki, Greece

Preoperative Supine Time for Adrenal Venous Sampling (PSTAVS)

Summary:

This study aim to understand whether the length of preoperative supine time would affect the AVS outcome. Supine in bed before AVS is recommended for a desirable result of AVS according to guidelines. However, investigating study about the most optimal preoperative supine time before AVS is lacking. This is a single-center prospective randomized controlled study.

Status: Recruiting Trial Number: NCT05658705
Conditions: Primary aldosteronism
Interventions: Procedure: 15-min supine time; Procedure: 2-hour supine time
Locations: Hangzhou, Zhejiang, China

A Prospective Randomised Trial Comparing Radiofrequency Ablation With Laparoscopic Adrenalectomy as an Alternative Treatment for Unilateral Asymmetric Primary Aldosteronism (WAVE)

Summary:

The primary objective of WAVE is to test the hypothesis that RFA is non-inferior to surgery in the biochemical (and if so, in the clinical) cure of unilateral PA, according to the international consensus PASO criteria. Secondary objectives are to determine whether either intervention is superior to the other in relation to the following outcomes. Where no superiority of either intervention is established, non-inferiority of RFA against LA will be sought.

Status: Recruiting Trial Number: NCT05405101
Conditions: Primary aldosteronism
Interventions: Procedure: ablation of aldosterone secreting adenoma; Procedure: Unilateral adrenalectomy
Locations: St. Bartholomew’s Hospital, London, UK

Efficacy and Safety of Finerenone in Patients With Primary Aldosteronism: a Randomized, Controlled Trial

Summary:

This is a prospective and randomized study involving patients with primary aldosteronism(PA). All participants will be randomized into finerenone group (Intervention group) and spironolactone group (Control group) and to compare the antihypertensive effect in patients with PA.

Status: Recruiting Trial Number: NCT05924620
Conditions: Primary aldosteronism
Interventions: Drug: finerenone
Locations: Chongqing, Chongqing, China