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Our evolving understanding of primary aldosteronism

Current screening and diagnostic guidelines capture only a fraction of the more severe forms of primary aldosteronism and with very poor overall sensitivity. A revamping of current practice guidelines is needed, informed by our newer understanding of this disorder.

Single-Center Prospective Cohort Study on the Histopathology, Genotype, and Postsurgical Outcomes of Patients With Primary Aldosteronism

Adrenals with a nonclassical histopathology of unilateral primary aldosteronism are associated with a higher incidence of postsurgical disease persistence and increased aldosterone production from the unresected adrenal.

Outcomes of a Specialized Clinic on Rates of Investigation and Treatment of Primary Aldosteronism

In this cohort, less than 1% of patients expected to have PA were ever formally diagnosed and treated. These findings suggest that a system-level approach to assist with investigation and treatment of PA may be highly effective in closing care gaps and improving clinical outcomes.

Autonomous cortisol secretion influences psychopathological symptoms in patients with primary aldosteronism

Patients with PA who also had autonomous cortisol secretion (ACS) had improved scores for anxiety and depression following treatment for PA. Women without ACS also showed improvement after treatment, while men without ACS did not.

Aldosterone sensitivity: an opportunity to explore the pathogenesis of hypertension

Blood pressure sensitivity to aldosterone may exist across a broad spectrum that differs across race/ethnic groups and perhaps, within persons.

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The Primary Aldosteronism Foundation is a registered 501(c)(3) public charity. Donations are tax deductible in the US.

©2021 Primary Aldosteronism Foundation

The Primary Aldosteronism Foundation is a registered 501(c)(3) public charity. Donations are tax deductible in the US.