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  • Cardiac Structure and Function Across the Spectrum of Aldosteronism: the Atherosclerosis Risk in Communities Study May 18, 2022
    Hypertension. 2022 May 18:101161HYPERTENSIONAHA12219134. doi: 10.1161/HYPERTENSIONAHA.122.19134. Online ahead of print.ABSTRACTBACKGROUND: Aldosterone production and mineralocorticoid receptor activation are implicated in myocardial fibrosis and cardiovascular events.METHODS: Cardiac structure and function were assessed in 4547 participants without prevalent heart failure (HF) in the ARIC study (Atherosclerosis Risk in Communities), with echocardiography, aldosterone, and plasma renin activity measurement (2011-2013).…
    Docwire News
  • CinCor Pharma to Present at Upcoming Investor Conferences May 17, 2022
    WALTHAM, Mass., May 17, 2022 (GLOBE NEWSWIRE) -- CinCor Pharma, Inc. (NASDAQ: CINC) today announced that management will present at the H.C. Wainwright 2022 Global Investment Conference taking place on May 23-26 virtually and in Miami, Florida, and at the UBS 2022 Global Healthcare Conference taking place on May 23-25 in New York, New York. […]
    CinCor Pharma Inc
  • Primary Aldosteronism More Prevalent in Patients With Cardioembolic Stroke and Atrial Fibrillation May 6, 2022
    Front Endocrinol (Lausanne). 2022 Apr 19;13:869980. doi: 10.3389/fendo.2022.869980. eCollection 2022.ABSTRACTBACKGROUND: Primary aldosteronism (PA) is the most common cause of secondary hypertension, and patients are at an increased risk of atrial fibrillation (AF) and stroke. We assessed the prevalence of PA in patients with recent stroke.METHODS: We recruited 300 patients admitted to an acute stroke unit…
    Docwire News
  • PET tracer shows promise imaging high cholesterol activity May 2, 2022
    A new PET radiotracer is safe for humans and could provide a noninvasive approach for diagnosing aldosteronism, a condition linked to high cholesterol and heart disease, according to a study published April 28 in the Journal of Nuclear Medicine.
    Will Morton, AuntMinnie.com staff writer
  • Low Renin Hypertension: Causes, Treatment, and More April 27, 2022
    Low levels of the enzyme renin may be behind your high blood pressure. Learn about low renin hypertension, its causes, subtypes, and how to treat it.
    Healthline
  • Medical mystery: Despite a ‘bucketload’ of drugs, his blood pressure was perilously high April 26, 2022
    Researchers estimate that 5 to 10 percent of people with high blood pressure and 20 percent of those with resistant hypertension have PA. Most don’t know it because they have never been tested.
    Sandra G. Boodman
  • Despite a ‘bucketload’ of drugs, his blood pressure was perilously high April 23, 2022
    His doctors told him again and again he had essential hypertension — high blood pressure with no underlying cause. But it did have a cause.
    Sandra G. Boodman

Conferences and Events

Notable Publications of the Year

ARR Performance

Performance varied widely based on patient population and diagnostic criteria, especially with respect to sensitivity. No single ARR threshold could be recommended.

Common Mechanisms Between Unilateral and Bilateral PA

Patients with partial and absent biochemical cure exhibited a lower lateralization index, suggesting asymmetric aldosterone production in BAH. Somatic mutations in their adrenal glands indicate common mechanisms underlying BAH and APA.

Tolerability and Efficacy of Medical Therapy

Side effects were experienced by 52.3% of patients, with 10.3% switching, 22.6% decreasing dose, and 11.0% stopping medications.

Outcomes of Subtypes of Classical APAs

Aldosterone-producing micronodules were identified in 51.3% of the adrenal glands; these patients showed lower likelihood (42.1%) of complete clinical success.

Acute Kidney Injury Post-Adrenalectomy

25% of patients had postoperative AKI after unilateral adrenalectomy. Preoperative albuminuria was an independent predictor of the progression of CKD.

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Primary Aldosteronism Foundation

The Primary Aldosteronism Foundation is a registered 501(c)(3) public charity. Donations are tax deductible in the US.

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