The objective of the study was to obtain information about the effect of prolonged aldosterone excess on kidney function. We determined kidney function changes defined by cystatin C-based estimations of glomerular filtration rate (CysC-GFR). Pretreatment proteinuria and intrarenal Doppler velocimetric indices in primary aldosteronism were examined and followed after adrenalectomy or spironolactone treatment. Our data suggest that prolonged hyperaldosteronism will cause relative kidney hyperfiltration and reversible intrarenal vascular structural changes, which disguise the consequent renal injury, including declining GFR and proteinuria. Adrenalectomy and spironolactone treatment exert different clinical impacts toward kidney damage even with a similar blood pressure-lowering effect.
Authors: Wu Vin-Cent, Kuo Chin-Chi, Wang Shuo-Meng, Liu Kao-Lang, Huang Kuo-How, Lin Yen-Hung, Chu Tzong-Shinn, Chang Hung-Wei, Lin Chien-Yu, Tsai Chia-Ti, Lin Lian-Yu, Chueh Shih-Chieh, Kao Tze-Wah, Chen Yung-Ming, Chiang Wen-Chih, Tsai Tun-Jun, Ho Yi-Luwn, Lin Shuei-Liong, Wang Wei-Jei, Wu Kwan-Dun
Keywords: aldosteronism and kidney function, cystatin C, eGFR
DOI Number: 10.1097/HJH.0b013e3283495cbb Publication Year: 2011
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