Risk of Major Cardiovascular and Neurologic Events With Obstructive Sleep Apnea Among Patients With Atrial Fibrillation


Obstructive sleep apnea (OSA) is a known risk factor for atrial fibrillation (AF). However, it remains unclear whether OSA is independently associated with worse cardiovascular and neurological outcomes in patients with AF. We used the ORBIT-AF I and ORBIT-AF II to conduct a retrospective cohort study of 22,760 patients with AF with and without OSA. Adjusted multivariable Cox proportional hazards models was used to determine whether OSA was associated with increased risk for major adverse cardiac and neurologic events (MACNEs) (cardiovascular death, myocardial infarction, stroke/transient ischemic attack/non–central nervous system embolism (stroke/SE), and new-onset heart failure], combined and individually. Among patients with AF, OSA is an independent risk factor for MACNE and, more specifically, stroke/SE.

Authors: Frederik Dalgaard, Rebecca North, Karen Pieper, Gregg C. Fonarow, Peter R. Kowey, Bernard J. Gersh, D. Phil Kenneth, W. Mahaffey, Sean Pokorney, Benjamin A. Steinberg, Gerald Naccarrelli, Larry A. Allen, James A. Reiffe, Michael Ezekowitz, Daniel E. Singer, Paul S. Chan, Eric D. Peterson, Jonathan P. Piccini
Keywords: obstructive sleep apnea (OSA), atrial fibrillation (AFib), stroke
DOI Number: 10.1016/j.ahj.2020.01.001      Publication Year: 2020

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