Mitigating Risk of Aldosterone in Diabetic Kidney Disease


Aldosterone is an important driver of inflammation and fibrosis leading to renal and cardiovascular complications. MRA lower albuminuria but data showing prevention of end-stage kidney disease are lacking. Side effects including hyperkalemia have previously prevented long-term studies in diabetic kidney disease but new treatment strategies with potassium binders, aldosterone synthase inhibitors and nonsteroidal MRA have been developed for clinical testing.

Authors: Frimodt-Møller, Mariea; Persson, Frederika; Rossing, Petera
Keywords: diabetic kidney disease, aldosterone synthase inhibitors, nonsteroidal mineralocorticoid receptor antagonist
DOI Number: 10.1097/MNH.0000000000000557      Publication Year: 2020

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