Clinical Presentation and Surgical Outcomes in Primary Aldosteronism Differ by Race


Primary aldosteronism (PA) is the most common cause of secondary hypertension; early diagnosis and intervention correlate with outcomes. We hypothesized that race may influence clinical presentation and outcomes. We conducted a retrospective analysis of patients with PA (1997‐2017) who underwent adrenal vein sampling (AVS). Patients were classified by self‐reported race as black or non‐black. Improvement was defined as postoperative decrease in mean arterial pressure (MAP), antihypertensive medications (AHM), or both. Black patients present with longer duration of hypertension and more comorbidities. They are equally likely to lateralize on AVS, suggesting similar disease phenotype. However, black patients demonstrate less improvement with adrenalectomy; this may reflect a delay in diagnosis or concomitant essential hypertension.

Authors: Victoria M. Gershuni, Jae P. Ermer, Rachel R. Kelz, Robert E. Roses, Debbie L. Cohen, Scott O. Trerotola, Douglas L. Fraker, Heather Wachtel
Keywords: adrenal, aldosteronoma, disparities, hypertension, primary aldosteronism, race
DOI Number: 10.1002/jso.25806      Publication Year: 2020

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