African Americans have a high prevalence of hypertension and hypertension-related vascular disease. We previously reported that plasma aldosterone concentrations are relatively high in hypertensive African Americans. This study evaluates the hypothesis that hypertension and hypertension-related alterations of peripheral vascular and renal vascular function are associated with aldosterone. Twenty four-hour blood pressures, cardiac output, renal blood flow (RBF), plasma renin activity (PRA), and plasma aldosterone were measured in hypertensive and normotensive African Americans. Hemodynamic measurements were repeated in response to graded infusions of norepinephrine (NE). Aldosterone may contribute to hypertension and to hypertension-related alterations of peripheral vascular and renal vascular function in African Americans.
Authors: Theodore A. Kotchen, Jane M. Kotchen, Clarence E. Grim, Shanthi Krishnaswami, Srividya Kidambi
Keywords: aldosterone, hypertension, African-Americans, vascular disease
DOI Number: 10.1038/ajh.2008.327 Publication Year: 2009
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