Location: London, UK
Specialties: Endocrinology, Clinical Pharmacology
Areas of Practice: In his laboratory and clinical research, Professor Brown has sought to discover causes of hypertension, and to optimise its management either by achieving complete cure, e.g. by removal of a hormone-producing adrenal tumour (pheochromocytoma, Conn’s), or by finding the right drug for the right patient. His current research is mainly focussed on the adrenal gland, and the small aldosterone-producing adenomas which are a common cause of hypertension – unrecognised in 99% of cases. In an NIHR project, he and his colleagues are comparing their newly developed technique of using a PET scan and metomidate with the invasive test of adrenal vein sampling, for their accuracy in predicting cure of hypertension by adrenalectomy. In a BHF-funded project, they are also evaluating a less invasive alternative to surgery, namely ultrasound guided endoscopic radiofrequency ablation of the adenoma.
Affiliations: William Harvey Research Institute