Animal models have demonstrated the role of aldosterone in left ventricular remodeling involving fibrosis, apoptosis and hypertrophy. Myocardial fibrosis is a risk factor for serious arrhythmia and sudden death in ischemic and idiopathic hypertrophic heart disease. Itis accepted that patients with primary aldosteronism have a higher prevalence of LV hypertrophy , arterial involvement and increased cardiovascular risk. In humans, a link has been demonstrated between aldosterone and heart failure as well as the benefit of the administration of an anti -aldosterone drug to lower mortality in this population ,regardless of blood pressure level . The administration of spironolactone ( aldosterone ) in hypertensive rats has prevented the occurrence of aortic fibrosis . Plasma aldosteronism inhumans has been associated with inflammation, fibrosis and aortic stiffness . However,primary aldosteronism is generally associated with so-called secondary hypertension . Chronic Hypertension alone is a recognized etiological factor of myocardial hypertrophy ( myocardial fibrosis very advanced ) . The purpose of this study is to investigate the effects of MRI hyperaldosteronism on the heart.
Study Name: Study of Myocardial Interstitial Fibrosis in Hyperaldosteronism
Conditions: Primary Hyperaldosteronism, Secondary, Hyperaldosteronism, Essential Hypertension, Healthy
Interventions: Other: non interventional study
Locations: Centre d\’investigation Clinique, hopital Europeen George Pompidou, Paris, France
Study link: https://ClinicalTrials.gov/show/NCT02938910
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