This study evaluates if :1 ) the plasma aldosterone concentration and blood pressure change in response to roxithromycin could be useful for the screening of PA patients carrying a KCNJ5-mutated APA; 2) the change of PAC in response to mutated KCNJ5 channel is truly occurring in KCNJ5-mutation APA.
Study Name: Macrolides for KCNJ5 – Mutated Aldosterone-Producing Adenoma (MAPA)
Conditions: Primary aldosteronism
Interventions: Drug: Clarithromycin
Locations: Department of Medicine – DIMED, University of Padova, Italy, Padova, Italy
Study link: https://ClinicalTrials.gov/show/NCT03414918
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