This video is primarily intended for physicians responsible for diagnosing patients with primary aldosteronism. Endocrine Society guidelines recommend a multi-tiered approach with both screening and provocative confirmatory testing for the diagnosis of primary aldosteronism. In this webinar, the presenters discuss the updates to the Endocrine Society practice guidelines for the management of primary aldosteronism and present data from a large study assessing the diagnostic accuracy of different renin assays to predict primary aldosteronism in hypertensive patients.