Traditionally, renin has been measured by a plasma renin activity (PRA) radioimmunoassay or liquid chromatography tandem mass spectrometry (LC-MS/MS). Direct renin concentration (DRC) immunoassays, also known as plasma renin concentration (PRC), have recently become more popular because of numerous benefits including walk-away automation, shorter turnaround times, and excellent reproducibility compared to PRA. In this webinar, we will review the key differences between PRA and DRC assays and discuss the utility of proposed age-specific ARR cutoffs for PA screening calculated using direct renin measurement.
