Interrelationship Between Vitamin D Insufficiency, Calcium Homeostasis, Hyperaldosteronism, and Autoimmunity


Grübler and collaborators have evaluated the effect of short‐term vitamin D supplementation on plasma aldosterone and renin in hypertensive patients with vitamin D insufficiency. The major finding was that vitamin D supplementation decreases plasma aldosterone. Previous studies have shown that vitamin D is also deficient in primary aldosteronism (PA). These studies confirm the interrelationship between renin, aldosterone, vitamin D, parathyroid hormone (PTH), mineralocorticoid receptor (MR), and vitamin D receptor (VDR). Both MR and VDR belong to the same superfamily of nuclear receptors and a possible interaction between these receptors and their agonists and antagonists could be hypothesized. VDR and MR are of the same family of receptors but they have opposite effects on immune and inflammatory responses. An interaction between these receptors and their expression could be involved as the cause or the consequence of PA or of some cases of hypertension.

Authors: Decio Armanini, Alessandra Andrisani, Guido Ambrosini, Gabriella Donà, Valentina Camozzi, Luciana Bordin, Chiara Sabbadin
Keywords: aldosteronism, vitamin D, calcium, autoimmunity
DOI Number: 10.1111.12822      Publication Year: 2016

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