Treatment of Primary Aldosteronism Reduces the Probability of Obstructive Sleep Apnea


Aldosterone excess is hypothesized to worsen obstructive sleep apnea (OSA) symptoms by promoting peripharyngeal edema. However, the extent to which primary aldosteronism (PA), hypertension, and body mass index (BMI) influence OSA pathogenesis remains unclear. We conducted a cross-sectional study of PA patients from our endocrine database to retrospectively evaluate OSA probability before and after adrenalectomy or medical management of PA. A control group of patients undergoing adrenalectomy for nonfunctioning benign adrenal masses was also evaluated. We categorized patients as high or low OSA probability after evaluation with the Berlin Questionnaire, a validated 10-question survey that explores sleep, fatigue, hypertension, and BMI. Both surgical and medical treatments of PA reduce sleep apnea probability independent of BMI and are associated with improvements in hypertension and fatigue. Improved screening for PA could reduce OSA burden.

Authors: Elizabeth Wang, Kathryn Chomsky-Higgins, Yufei Chen, Iheoma Nwaogu, Carolyn D. Seib, Wen T. Shen, Quan-Yang Duh, Insoo Suh
Keywords: obstructive sleep apnea, OSA, primary aldosteronism
DOI Number: 10.1016/j.jss.2018.10.040      Publication Year: 2019

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