The Spectrum of Subclinical Primary Aldosteronism and Incident Hypertension: A Cohort Study


Primary aldosteronism is recognized as a severe form of renin-independent aldosteronism that results in excessive mineralocorticoid receptor (MR) activation. The study investigated whether a spectrum of subclinical renin-independent aldosteronism that increases risk for hypertension exists among normotensive persons. Suppression of renin and higher aldosterone concentrations in the context of this renin suppression are associated with an increased risk for hypertension and possibly also with increased MR activity. These findings suggest a clinically relevant spectrum of subclinical primary aldosteronism (renin-independent aldosteronism) in normotension.

Authors: Jennifer M. Brown, Cassianne Robinson-Cohen, Miguel Angel Luque-Fernandez, Matthew A. Allison, Rene Baudrand, Joachim H. Ix, Bryan Kestenbaum, Ian H. de Boer, Anand Vaidya
Keywords: renin-independent aldosteronism, subclinical aldosteronism, hypertension
DOI Number: 10.7326/M17-0882      Publication Year: 2017

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