The Relationship Between Plasma Renin Activity and Serum Lipid Profiles in Patients With Primary Arterial Hypertension


The aim of the study was to evaluate clinical and biochemical differences between patients with low-renin and high-renin primary arterial hypertension (AH), mainly in reference to serum lipids, and to identify factors determining lipid concentrations. In untreated patients with AH stage 1 we measured plasma renin activity (PRA) and subdivided the group into low-renin (PRA < 0.65 ng/mL/h) and high-renin (PRA ⩾ 0.65 ng/mL/h) AH. We compared office and 24-h ambulatory blood pressure, serum aldosterone, lipids and selected biochemical parameters between subgroups. Factors determining lipid concentration in both subgroups were assessed in regression analysis. Higher serum levels of total and LDL-C characterized high-renin subjects, but the association between LDL-C level and PRA existed only in low-renin primary AH.

Authors: Tomasz Pizoń, Marek Rajzer, Wiktoria Wojciechowska, Małgorzata Wach-Pizoń, Tomasz Drożdż, Katarzyna Wróbel, Krystian Gruszka, Marta Rojek, Tomasz Kameczura, Artur Jurczyszyn, Janusz Kąkol, Danuta Czarnecka
Keywords: lipids, renin, plasma renin activity, low-density lipoprotein cholesterol
DOI Number: 10.1177/1470320318810022      Publication Year: 2018

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