Specific Nongenomic Actions of Aldosterone


According to the traditional model, steroid hormones modulate gene transcription and protein synthesis. The considerable latency of these genomic steroid effects is the consequence of these time-consuming steps of action. Over the years, it has become increasingly clear that rapid actions of steroids exist that are incompatible with this “classic” genomic model of action. These rapid, nongenomic effects, which recently have been shown for virtually all groups of steroids, are likely to be transmitted by specific membrane receptors. For a better understanding of nongenomic aldosterone action even in a clinical context, future research will have to target the cloning of the first membrane receptor for aldosterone and the evaluation of the clinical relevance of rapid steroid effects in general.

Authors: Elisabeth Falkenstein, Michael Christ, Martin Feuring, Martin Wehling
Keywords: aldosterone, nongenomic action
DOI Number: 10.1046/j.1523-1755.2000.00980.x      Publication Year: 2000

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