Reassessment of Postural Stimulation Testing As a Simple Tool to Identify a Subgroup of Patients With Unilateral Primary Aldosteronism


Adrenal vein sampling (AVS) represents the current diagnostic gold standard for differentiation between unilateral and bilateral primary aldosteronism (PA). Postural stimulation testing (PST) has been used to provide additional diagnostic information. We analyzed 106 PST performed between 2008 and 2020. Diagnosis of PA and cause of PA were determined according to the Endocrine Society Clinical Practice Guideline, taking into account results of saline infusion testing, AVS, preoperative imaging and outcome after medical or surgical treatment. The high specificity of 100% for the detection of unilateral PA in patients with decreased aldosterone by at least 28% after 4 hours, makes PST a simple, non-invasive contribution to subtype differentiation in PA.

Authors: Carmina Teresa Fuss, Katharina Brohm, Martin Fassnacht, Matthias Kroiss, Stefanie Hahner
Keywords: adrenal vein sampling, postural stimulation testing
DOI Number: 10.1210/clinem/dgab611      Publication Year: 2021

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