Primary aldosteronism (PA) is the most common cause of secondary hypertension. Aldosterone excess can cause DNA damage in vitro and in vivo. Single case reports have indicated a coincidence of PA with renal cell carcinoma and other tumors. However, the prevalence of benign and malignant neoplasms in patients with PA has not yet been studied. In the multicenter MEPHISTO study, the prevalence of benign and malignant tumors was investigated in 335 patients with confirmed PA. Matched hypertensive subjects from the population-based Study of Health in Pomerania cohort served as controls. Compared to hypertensive controls, the prevalence of malignancies was positively correlated with aldosterone levels, tended to be higher in PA patients, but did not differ significantly.
Authors: K. Lang, K. Weber, M. Quinkler, A. S. Dietz, H. Wallaschofski, A. Hannemann, N. Friedrichs, L. C. Rump, B. Heinze, C. T. Fuss, I. Quack, H. S. Willenberg, M. Reincke, B. Allolio, S. Hahner
Keywords: primary aldosteronism, cancer
DOI Number: 10.1210/jc.2015-3405 Publication Year: 2016
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