Prevalence and Clinical Manifestations of Primary Aldosteronism Encountered in Primary Care Practice


Despite being widely recognized as the most common form of secondary hypertension, among the general hypertensive population the true prevalence of primary aldosteronism (PA) and its main subtypes, aldosterone-producing adenoma (APA) and bilateral adrenal hyperplasia (BAH), remains a matter of debate. This study sought to determine the prevalence and clinical phenotype of PA in a large cohort of unselected patients with hypertension, consecutively referred to our hypertension unit, by 19 general practitioners from Torino, Italy. Our results demonstrated that PA is a frequent cause of secondary hypertension, even in the general population of patients with hypertension, and indicates that most of these patients should be screened for PA.

Authors: Silvia Monticone, Jacopo Burrello, DavideTizzani, Chiara Bertello, Andrea Viola, Fabrizio Buffolo, Luisa Gabetti, Giulio Mengozzi, Tracy A. Williams, Franco Rabbia, Franco Veglio, Paolo Mulatero
Keywords: adrenal vein sampling, aldosterone-producing adenoma, bilateral adrenal hyperplasia, hypertension, renin
DOI Number: 10.1016/j.jacc.2017.01.052      Publication Year: 2017

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