Parametric Mapping for 11C-metomidate PET-computed Tomography Imaging in the Study of Primary Aldosteronism


11C-metomidate (11C-MTO) PET-computed tomography (CT) imaging has shown good sensitivity and specificity for the classification of bilateral or unilateral overexpression of aldosterone. This work seeks to investigate the usefulness of parametric maps via kinetic modeling of 11C-metomidate data into the clinical diagnosis pathway. Twenty-five patients were injected with 172 ± 12 MBq of 11C-metomidate and a dynamic PET scan performed of the adrenal glands. A blood time-activity curve was drawn from a volume of interest in the left ventricle and converted to a plasma time-activity curve. Metabolite correction was performed with a population-based correction. We performed regional-based graphical Patlak analysis to calculate the regional uptake rate constant Ki(REG), and also calculated parametric maps of Ki(VOX) using a voxel-based technique. Our work demonstrates that parametric Ki(VOX) was able to successfully differentiate between patients with bilateral hyperplasia and patients with unilateral adrenal adenoma in our cohort and that Ki may be considered be an additional useful metric to SUV in 11C-metomidate PET-CT imaging.

Authors: Jim O’ Doherty, Sophie O’ Doherty, Edward G Robins, Anthonin Reilhac
Keywords: 11C-metomidate PET-computed tomography, imaging, sensitivity, specificity, parametric maps, kinetic modeling
DOI Number: 10.1097/MNM.0000000000001477      Publication Year: 2021

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