Primary Aldosteronism is Associated With Decreased Low-density and High‐density Lipoprotein Particle Concentrations and Increased GlycA, a Pro‐inflammatory Glycoprotein Biomarker


Primary aldosteronism (PA) may confer increased cardiovascular risk beyond effects on systemic blood pressure, but contributing mechanisms remain incompletely understood. We compared  plasma (apo)lipoproteins and lipoprotein particle characteristics, GlycA, a pro‐inflammatory glycoprotein biomarker of enhanced chronic inflammation, and plasma total branched‐chain amino acids (BCAA), measured using nuclear magnetic resonance (NMR) spectroscopy, between patients with PA, control subjects without hypertension, subjects with untreated hypertension and subjects with treated hypertension. Primary aldosteronism is associated with lower concentrations of LDL and HDL particles and to some extent also with lower TG and TRL particle concentrations. PA is also characterized by increased GlycA levels, indicating enhanced low-grade chronic inflammation. Low HDL particle concentrations and increased GlycA could contribute to accelerated cardiovascular disease development in PA.

Authors: Annika M. A. Berends, Edward Buitenwerf, Eke G. Gruppen, Wim J. Sluiter, Stephan J. L. Bakker, Margery A. Connelly, Michiel N. Kerstens, Robin P. F. Dullaart
Keywords: LDL, HDL, GlycA, TG, TRL, inflammatory markers, cholesterol
DOI Number: 10.1111/cen.13891      Publication Year: 2018

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