Masking by Hypokalemia—Primary Aldosteronism With Undetectable Aldosterone

Abstract/Summary:

Primary aldosteronism is the most common cause of secondary hypertension; however, the dynamic regulation of aldosterone by potassium is less well studied and current diagnostic recommendations are imprecise. We describe a young man who presented with resistant hypertension and severe hypokalemia. The workup initially revealed undetectable aldosterone despite acute potassium repletion. Chronic potassium supplementation eventually uncovered hyperaldosteronism. In situ genetic studies revealed a gain-of-function KCNJ5 mutation within an aldosterone-producing adenoma that was clinically responsive to changes in extracellular potassium. We highlight a unique presentation of Conn’s syndrome and discuss the implications for the molecular mechanisms of potassium regulation of aldosterone.

Authors: Rebecca A Boyle, Jessica E Baker, Vivek Charu, William E Rainey, Vivek Bhalla
Keywords: hypokalemia, potassium channel, somatic mutation
DOI Number: 10.1093/ckj/sfaa150      Publication Year: 2020

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©2021 Primary Aldosteronism Foundation

The Primary Aldosteronism Foundation is a registered 501(c)(3) public charity. Donations are tax deductible in the US.