Left Ventricular Remodeling in Patients With Primary Aldosteronism: A Prospective Cardiac Magnetic Resonance Imaging Study


This study used cardiac magnetic resonance imaging (MRI) to compare the characteristics of left ventricular remodeling in patients with primary aldosteronism (PA) with those of patients with essential hypertension (EH) and healthy controls (HCs). This prospective study enrolled 35 patients with PA, in addition to 35 age- and sex-matched patients with EH, and 35 age- and sex-matched HCs, all of whom underwent comprehensive clinical and cardiac MRI examinations. The analysis of variance was used to detect the differences in the characteristics of left ventricular remodeling among the three groups. Univariable and multivariable linear regression analyses were used to determine the relationships between left ventricular remodeling and the physiological variables. Patients with PA showed a greater degree of ventricular hypertrophy and enlargement, as well as myocardial fibrosis, compared to those with EH. Cardiac MRI T1 mapping can detect left ventricular myocardial fibrosis in patients with PA.

Authors: Tao Wu, Yan Ren, Wei Wang, Wei Cheng, Fangli Zhou, Shuai He, Xiumin Liu, Lei Li, Lu Tang, Qiao Deng, Xiaoyue Zhou, Yucheng Chen, and Jiayu Sun
Keywords: ventricular remodeling, ventricular enlargement, myocardial fibrosis, cardiac magnetic resonance imaging
DOI Number: 10.3348/kjr.2020.1291      Publication Year: 2021

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