Hyperparathyroidism in Patients With Primary Aldosteronism: Cross-sectional and Interventional Data from the GECOH Study


Experimental studies suggest that aldosterone induces hypercalciuria and might contribute to hyperparathyroidism. We aimed to test for differences in PTH levels and parameters of calcium and vitamin D metabolism in patients with primary aldosteronism (PA) compared with patients with essential hypertension (EH) and to evaluate the impact of PA treatment on these laboratory values. Our results suggest that PA contributes to secondary hyperparathyroidism. Further studies are warranted to evaluate whether PTH has implications for PA diagnostics and whether mineralocorticoid receptor antagonists have a general impact on PTH and calcium metabolism.

Authors: Stefan Pilz, Katharina Kienreich, Christiane Drechsler, Eberhard Ritz, Astrid Fahrleitner-Pammer, Martin Gaksch, Andreas Meinitzer, Winfried März, Thomas R. Pieber, Andreas Tomaschitz
Keywords: aldosteronism, hyperparathyroidism
DOI Number: 10.1210/jc.2011-2183      Publication Year: 2012

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