Increasing evidences support the concept of a gastro‐renal communication in the excretion of a sodium load. Enterokines are released from the intestine into the circulation in response to sodium intake that interacts with dopamine receptors in the kidney to regulate sodium excretion and keep the blood pressure in the normal range. The aberrant gastro‐renal natriuretic signaling axis may be involved in the pathogenesis of hypertension. Increased understanding of the role of the gastro‐renal axis in the regulation of renal function may give us a novel insight into the pathogenesis of hypertension and provide a new treatment strategy for hypertension.
