Errors in Potassium Measurement: A Laboratory Perspective for the Clinician

Abstract/Summary:

Errors in potassium measurement can cause pseudohyperkalemia, where serum potassium is falsely elevated. Usually, these are recognized either by the laboratory or the clinician. However, the same factors that cause pseudohyperkalemia can mask hypokalemia by pushing measured values into the reference interval. These cases require a high-index of suspicion by the clinician as they cannot be easily identified in the laboratory. This article discusses the causes and mechanisms of spuriously elevated potassium, and current recommendations to minimize those factors. “Reverse” pseudohyperkalemia and the role of correction factors are also discussed. Relevant articles were identified by a literature search performed on PubMed using the terms “pseudohyperkalemia,” “reverse pseudohyperkalemia,” “factitious hyperkalemia,” “spurious hyperkalemia,” and “masked hypokalemia.”

Authors: Jaya R Asirvatham, Viju Moses, Loring Bjornson
Keywords: pseudohyperkalemia, masked hypokalemia, factitious hyperkalemia, spurious hyperkalemia, hyperkalemia, hypokalemia
DOI Number: 10.4103/1947-2714.110426      Publication Year: 2013

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©2021 Primary Aldosteronism Foundation

The Primary Aldosteronism Foundation is a registered 501(c)(3) public charity. Donations are tax deductible in the US.