Dietary Sodium Restriction Increases the Risk of Misinterpreting Mild Cases of Primary Aldosteronism


The aldosterone to renin ratio (ARR) is recommended to screen for primary aldosteronism (PA). Sodium restriction is recommended in hypertension; however, it can significantly raise PRA, normalize the ARR, and result in false interpretation of PA screening. Milder phenotypes of PA, where PRA is not as suppressed, are most susceptible to dietary sodium influences on renin and ARR. Optimal screening for PA should occur under conditions of high dietary sodium intake.

Authors: Rene Baudrand, Francisco J Guarda, Jasmine Torrey, Gordon Williams, Anand Vaidya
Keywords: primary aldosteronism diagnosis, sodium restricted diet
DOI Number: 10.1210/jc.2016-1963      Publication Year: 2016

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