Diagnostic Accuracy of Adrenal Imaging for Subtype Diagnosis in Primary Aldosteronism: Systematic Review and Meta-analysis

Abstract/Summary:

Accurate subtype classification in primary aldosteronism (PA) is critical in assessing the optimal treatment options. This study aimed to evaluate the diagnostic accuracy of adrenal imaging for unilateral PA classification. Systematic searches of PubMed, EMBASE and the Cochrane databases were performed from 1 January 2000 to 1 February 2020, for all studies that used CT or MRI in determining unilateral PA and validated the results against invasive adrenal vein sampling (AVS). Summary diagnostic accuracies were assessed using a bivariate random-effects model. Subgroup analyses, meta-regression and sensitivity analysis were performed to explore the possible sources of heterogeneity. CT/MRI is not a reliable alternative to invasive AVS without excellent sensitivity or specificity for correctly identifying unilateral PA. Even in young patients (≤40 years), 21% of patients would have undergone unnecessary adrenalectomy based on imaging results alone.

Authors: Yaqiong Zhou, Dan Wang, Licheng Jiang, Fei Ran, Sichao Chen, Peng Zhou, Peijian Wang
Keywords: adrenal venous sampling, MRI, CT, subtype, diagnosis
DOI Number: 10.1136/bmjopen-2020-038489      Publication Year: 2020

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©2021 Primary Aldosteronism Foundation

The Primary Aldosteronism Foundation is a registered 501(c)(3) public charity. Donations are tax deductible in the US.