Confounders of the Aldosterone-to-renin Ratio when Used As a Screening Test in Hypertensive Patients: A Critical Analysis of the Literature


The aldosterone-to-renin ratio (ARR) is a common screening test for primary aldosteronism in hypertensives. However, there are many factors which could confound the ARR test result and reduce the accuracy of this test. The present review’s objective is to identify these factors and to describe to what extent they affect the ARR. Our analysis revealed that sex, age, posture, and sodium-intake influence the ARR, whereas assay techniques do not. Race and body mass index have an uncertain effect on the ARR. We conclude that several factors can affect the ARR. Not taking these factors into account could lead to misinterpretation of the ARR.

Authors: Gregory P Veldhuizen, Rawan M Alnazer, Abraham A Kroon, Peter W de Leeuw
Keywords: aldosterone, hyperaldosteronism, hypertension, renin, screening
DOI Number: 10.1111/jch.14117      Publication Year: 2020

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