Cholesterol Delivery to the Adrenal Glands Estimated by Adrenal Venous Sampling: An in Vivo Model to Determine the Contribution of Circulating Lipoproteins to Steroidogenesis in Humans


Cholesterol, required for adrenal steroid hormone synthesis, is at least in part derived from circulating lipoproteins. The contribution of high-density lipoproteins (HDL) and low-density lipoproteins (LDL) to adrenal steroidogenesis in humans is unclear. The aim of the study was to determine the extent to which HDL and LDL are taken up by the adrenal glands using samples obtained during adrenal venous sampling (AVS). AVS was successfully performed in 23 patients with primary aldosteronism. Samples were drawn from both adrenal veins and inferior vena cava (IVC). HDL cholesterol (HDL-C) and lipoprotein particle profiles were determined by nuclear magnetic resonance spectroscopy. Apolipoprotein (apo) A-I and apoB were assayed by immunoturbidimetry. In vivo observations suggested that circulating LDL may contribute to adrenal steroidogenesis in humans as inferred from adrenal venous-IVC apoB concentration differences. AVS is a feasible method to investigate the relationships between lipoproteins and steroidogenesis.

Authors: Edward Buitenwerf, Robin P.F. Dullaart, Anneke C. Muller Kobold, Thera P. Links, Wim J. Sluiter, Margery A. Connelly, Michiel N. Kerstens
Keywords: adrenal steroidogenesis, adrenal venous sampling, low-density lipoprotein particles, high-density lipoprotein particles
DOI Number: 10.1016/j.jacl.2017.03.018      Publication Year: 2017

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