Cardiovascular Outcomes in Patients With Primary Aldosteronism After Treatment


Experimental and human studies demonstrate that long-term exposure to elevated aldosterone levels results in cardiac and vascular damage. We investigated long-term cardiovascular outcomes in patients with primary aldosteronism after surgical or medical treatment. Fifty-four patients with or without evidence of adrenal adenomas were prospectively followed up for a mean of 7.4 years after treatment with adrenalectomy or spironolactone. Patients with primary aldosteronism were compared with patients with essential hypertension and were treated to reach a blood pressure of less than 140/90 mm Hg. The main outcome measure was a combined cardiovascular end point comprising myocardial infarction, stroke, any type of revascularization procedure, and sustained arrhythmias. Primary aldosteronism is associated with a cardiovascular complication rate out of proportion to blood pressure levels that benefits substantially from surgical and medical treatment in the long term.

Authors: Cristiana Catena, GianLuca Colussi, Elisa Nadalini, Alessandra Chiuch, Sara Baroselli, Roberta Lapenna, Leonardo A. Sechi
Keywords: aldosteronism cardiovascular outcomes, treatment outcomes
DOI Number: 10.1001/archinternmed.2007.33      Publication Year: 2008

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