The Adrenal Vein Sampling International Study (AVIS) for Identifying the Major Subtypes of Primary Aldosteronism


In patients who seek surgical cure of primary aldosteronism (PA), The Endocrine Society Guidelines recommend the use of adrenal vein sampling (AVS), which is invasive, technically challenging, difficult to interpret, and commonly held to be risky. The aim of this study was to determine the complication rate of AVS and the ways in which it is performed and interpreted at major referral centers. The Adrenal Vein Sampling International Study is an observational, retrospective, multicenter study conducted at major referral centers for endocrine hypertension worldwide. The protocols, interpretation, and costs of AVS were measured, as well as the rate of adrenal vein rupture and the rate of use of AVS. Despite carrying a minimal risk of adrenal vein rupture and at variance with the guidelines, AVS is not used systematically at major referral centers worldwide. These findings represent an argument for defining guidelines for this clinically important but technically demanding procedure.

Authors: Gian Paolo Rossi, Marlena Barisa, Bruno Allolio, Richard J. Auchus, Laurence Amar, Debbie Cohen, Christoph Degenhart, Jaap Deinum, Evelyn Fischer, Richard Gordon, Ralph Kickuth, Gregory Kline, Andre Lacroix, Steven Magill, Diego Miotto, Mitsuhide Naruse, Tetsuo Nishikawa, Masao Omura, Eduardo Pimenta, Pierre-Francois Plouin, Marcus Quinkler, Martin Reincke, Ermanno Rossi, Lars Christian Rump, Fumitoshi Satoh, Leo Schultze Kool, Teresa Maria Seccia, Michael Stowasser, Akiyo Tanabe, Scott Trerotola, Oliver Vonend, Jiri Widimsky Jr., Kwan-Dun Wu, Vin-Cent Wu, Achille Cesare Pessina
Keywords: adrenal venous sampling, AVS complication rate
DOI Number: 10.1210/jc.2011-2830      Publication Year: 2012

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