Appropriate Timing for a Biochemical Evaluation After Adrenalectomy for Unilateral Aldosterone‐producing Adenoma


The oversecretion of plasma aldosterone by unilateral aldosterone‐producing adenoma (APA) can be cured by adrenalectomy. However, the time needed for the endocrine environment to normalize remains unclear. The goal of this study was to clarify adequate timing for a biochemical evaluation in unilateral APA patients after adrenalectomy. A total of 166 unilateral APA patients were retrospectively reviewed. We evaluated the plasma aldosterone concentration (PAC) (pg/mL), active renin concentration (ARC) (pg/mL), aldosterone‐renin ratio (ARR; PAC/ARC), serum potassium concentration and estimated glomerular filtration rate (eGFR) at 1, 3 and 6 postoperation months (POM). The appropriate timing for a biochemical evaluation of unilateral APA patients treated with laparoscopic adrenalectomy appears to be 3 months or more after surgery.

Authors: Kimiharu Takamatsu, Toshikazu Takeda, Seiya Hattori, Nobuyuki Tanaka, Shinya Morita, Kazuhiro Matsumoto, Takeo Kosaka, Ryuichi Mizuno, Toshiaki Shinojima, Eiji Kikuchi, Hiroshi Asanuma, Isao Kurihara, Hiroshi Itoh, Mototsugu Oya
Keywords: adrenalectomy, timing of biochemical evaluation
DOI Number: 10.1111/cen.14176      Publication Year: 2020

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