Aldosterone Excess Impairs First Phase Insulin Secretion in Primary Aldosteronism


Primary aldosteronism (PA) represents the most frequent cause of secondary arterial hypertension. Conflicting data have been published regarding the effect of aldosterone excess on glucose metabolism. Our aim was to analyze insulin sensitivity and β-cell function in a cohort of PA patients. Prospective follow-up investigations were performed in a subgroup of patients before and after adrenalectomy to assess the metabolic outcome. Twenty-two consecutive patients with both unilateral aldosterone-producing adenoma and bilateral idiopathic adrenal hyperplasia were recruited through the Munich center of the German Conn’s Registry. The control group of patients with essential hypertension (n = 11) of corresponding age and body mass index was recruited from our hypertension unit. A normotensive cohort (n = 11) served as a further control group. Aldosterone excess has a direct negative effect on β-cell function in patients with PA. After adrenalectomy, glucose-induced first-phase insulin secretion improves significantly in the patients.

Authors: Evelyn Fischer, Christian Adolf, Anna Pallauf, Cornelia Then, Martin Bidlingmaier, Felix Beuschlein, Jochen Seissler, Martin Reincke
Keywords: aldosterone, insulin, metabolic disorders
DOI Number: 10.1210/jc.2012-3934      Publication Year: 2012

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