There is a paucity of data for the association of aldosterone and PRA with incident CVD or all-cause mortality among community-dwelling African Americans. This study examined the association of aldosterone and plasma renin activity (PRA) with incident cardiovascular disease (CVD), using a composite endpoint of coronary heart disease, stroke, and/or heart failure and mortality among African Americans in the Jackson Heart Study. A total of 4,985 African American adults, 21 to 94 years of age, were followed for 12 years. Aldosterone, PRA, and cardiovascular risk factors were collected at baseline (from 2000 to 2004). Incident events included coronary heart disease and stroke (assessed from 2000 to 2011) and heart failure (assessed from 2005 to 2011). Cox models were used to estimate hazard ratios (HRs) for incident CVD and mortality, adjusting for age, sex, education, occupation, current smoking, physical activity, dietary intake, and body mass index. Elevated aldosterone and PRA may play a significant role in the development of CVD and all-cause mortality among African Americans.

Authors: Joshua J. Joseph, Justin B. Echouffo-Tcheugui, Rita R. Kalyani, Hsin-Chieh Yeh, Alain G. Bertoni, Valery S. Effoe, Ramon Casanova, Mario Sims, Wen-Chih Wu, Gary S. Wand, Adolfo Correa, Sherita H. Golden
Keywords: aldosterone, all-cause mortality, cardiovascular disease, plasma renin activity
DOI Number: 10.1016/j.jchf.2017.05.012      Publication Year: 2017

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