Abstract/Summary:

After unilateral adrenalectomy (uADX) in patients with a unilateral aldosterone-producing adenoma (APA), the remaining contralateral adrenal gland is generally considered sufficient to support life. However, few studies have compared adrenal reserve function before and after uADX. Therefore, we closely evaluated adrenal cortisol secretory function before and after uADX in patients with unilateral APA. The adrenal cortisol secretory response to ACTH stimulation is mildly reduced after uADX in patients with unilateral APA without SCS or Cushing’s syndrome, although their basal cortisol level is sustained by elevated ACTH. These data will be important as a point of discussion when patients with unilateral APA consider either uADX or specific pharmacotherapy as treatment options.

Authors: Honda Kyokoa, Sone Masakatsua, Tamura Naohisaa, Sonoyama Takuhiroa, Taura Daisukea, Kojima Katsutoshia, Fukuda Yorihidea, Tanaka Shirob, Yasuno Shinjic, Fujii Toshihitoa, Kinoshita Hideyukia, Ariyasu Hiroyukia, Kanamoto Naotetsua, Miura Masakoa, Yasoda Akihiroa, Arai Hiroshia, Ueshima Kenjic, Nakao Kazuwa
Keywords: adenoma, adrenal gland neoplasm, adrenalectomy, adrenocorticotropic hormone, Cushing Syndrome, hydrocortisone, hyperaldosteronism, dexamethasone
DOI Number: 10.1097/HJH.0b013e3283635789      Publication Year: 2013

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©2021 Primary Aldosteronism Foundation

The Primary Aldosteronism Foundation is a registered 501(c)(3) public charity. Donations are tax deductible in the US.