A Prospective Study of the Prevalence of Primary Aldosteronism in 1,125 Hypertensive Patients


The prevalence of curable forms of PA is currently unknown, although retrospective data suggest that it is not as low as commonly perceived. We prospectively investigated the prevalence of curable forms of primary aldosteronism (PA) in newly diagnosed hypertensive patients. A total of 1,180 patients (age 46 ± 12 years) were enrolled; a conclusive diagnosis was attained in 1,125 (95.3%). Of these, 54 (4.8%) had an APA and 72 (6.4%) had an IHA. There were more APA (62.5%) and fewer IHA cases (37.5%) at centers where AVS was available (p = 0.002); the opposite occurred where AVS was unavailable. In newly diagnosed hypertensive patients referred to hypertension centers, the prevalence of APA is high (4.8%). The availability of AVS is essential for an accurate identification of the adrenocortical pathologies underlying PA.

Authors: Gian Paolo Rossi, Giampaolo Bernini, Chiara Caliumi, Giovambattista Desideri , Bruno Fabris, Claudio Ferri, Chiara Ganzaroli, Gilberta Giacchetti, Claudio Letizia, Mauro Maccario, Francesca Mallamaci, Massimo Mannelli, Mee-Jung Mattarello, Angelica Moretti, Gaetana Palumbo, Gabriele Parenti, Enzo Porteri, Andrea Semplicini, Damiano Rizzoni, Ermanno Rossi, Marco Boscaro, Achille CesarePessina, Franco Mantero
Keywords: aldosteronism, prevalence
DOI Number: 10.1016/j.jacc.2006.07.059      Publication Year: 2006

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