Patients with unilateral primary aldosteronism (PA) can be cured with adrenalectomy, and adrenal vein sampling (AVS) remains the gold-standard test. However, AVS is invasive, technically-challenging and criteria for determining lateralization differ between centres. 11C-Metomidate PET/CT (MTO) imaging offers a promising non-invasive alternative for identifying unilateral PA. While most patients have congruent findings on both AVS and MTO, these tests may identify different subtypes of unilateral PA. Further genotyping of these tumors will be important to understand further the underlying pathophysiology and the utility of these localization tests.
Authors: Troy Puar, Colin Tan, Aaron Tong, Meifen Zhang, Chin Meng Khoo, Alvin Tan, Htoo Htoo, Anthonin Reilhac, Ashley Weekes, Ed Robins, Roger Foo
Keywords: PET/CT scan, 11C-Metomidate, adrenal venous sampling (AVS)
DOI Number: 10.1530/endoabs.63.P445 Publication Year: 2019
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