Summary

The study will investigate 27 hour profiles of hormones in the subcutaneous tissue of healthy subjects and patients with Addison’s, Congenital Adrenal Hyperplasia, Growth Hormone Deficiency, acromegaly, Cushings and Primary Hyperaldosteronism during conventional diagnostic and therapeutic follow-up.The 27 hour monitoring by ULTRADIAN takes into account the rhythm of hormones throughout the day. It is hoped that this information may in the future improve and simplify diagnostic procedures. Follow-up of patients in endocrinology still remains difficult including clinical signs of over and under-treatment, questionnaires of quality of life and blood testing necessitating often retesting. Simplification of the diagnostic procedure by obtaining detailed knowledge about the rhythm of hormones may contribute to the improvement and individualization of treatment and may decrease morbidity and mortality of endocrine patients

Study Name: Dynamic Hormone Diagnostics in Endocrine Disease
Status: Active
Conditions: Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Cushing Syndrome, Growth Hormone Deficiency, Acromegaly, Primary Hyperaldosteronism
Interventions: Other: 27 hour subcutaneous fluid sampling
Locations: Evangelissmos hospital, Athen, Greece; Haukeland University Hospital, Bergen, Norway; Karolinska Institutet, Stockholm, Sweden; Bristol University hospital, Bristol, United Kingdom
Study link: https://ClinicalTrials.gov/show/NCT02934399

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