Vascular and cardiac alterations are associated with aldosterone effects are evidenced in experimental models and aldosterone receptor blockade is of clear benefit in cardiac disease(heart failure). The study aims at assessing vascular and cardiac alterations in adults with a chronic increase in circulating aldosterone without hypertension. The investigated population will be patients with a rare disease, pseudohypoaldosteronism type 1, due to heterozygous inactivating mutations of the mineralocorticoid receptor.
Study Name: Cardiovascular Evaluation of Adult PHA 1 Patients
Conditions: Pseudohypoaldosteronism Type 1
Interventions: Observational only
Locations: Hospital Bichat, Paris, France
Study link: https://ClinicalTrials.gov/show/NCT00646828
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