Clinical Study


Primary aldosteronism is a common cause of hypertension. Recent evidence suggests that many patients with bilateral idiopathic hyperaldosteronism harbor gain-of-function somatic mutations in zona glomerulosa calcium channels that results in aldosterone production. This finding raises the possibility that calcium channel antagonists may be a targeted therapy to reduce aldosterone production in patients who harbor these mutations.

Study Name: Calcium Channel Blockade in Primary Aldosteronism (CCB-PA)
Status: Recruiting
Conditions: Primary aldosteronism
Interventions: Drug: Amlodipine
Locations: Brigham and Women’s Hospital, University of Michigan
Study link:

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