Primary aldosteronism (PA) is a disorder of the adrenal gland causing an autonomous overproduction of mineralocorticoids, leading to arterial hypertension. Although rare, it’s the most frequent cause of secondary hypertension. Early detection is important to avoid end organ damage, specifically cardiovascular and metabolic morbidity. Recent studies showed a positive correlation between patients with PA with lower bone density especially at the spine, with significant improvement post treatment, either medically or surgically. There was also a positive correlation between high aldosterone renin ratio with higher levels of intact parathyroid hormone (iPTH) which is responsible for cortical bone loss especially at the distal forearm.We hypothesize that our patients with PA have a higher level of iPTH, with lower bone density especially at the distal forearm, with improvement post treatment.
Study Name: The Effect of Disease-specific Treatment on Bone Turnover Markers in Patients With Primary Aldosteronism
Conditions: Primary aldosteronism
Interventions: Observational only
Locations: Hospital Universiti Kebangsaan Malaysia, Kuala Lumpur, WP Kuala Lumpur, Malaysia
Study link: https://ClinicalTrials.gov/show/NCT02216721
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