Summary

Primary aldosteronism (PA) is the most common endocrine cause of resistant hypertension. Surgery and medicine are the main treatment for PA by the current guidelines. However,only a small part of patients with PA meet the surgical criteria, and most of them have to take spironolactone or other antihypertensive drugs for long time. On the other side, long-term inhibition of aldosterone receptor may cause hyperkalemia, male breast hyperplasia and other adverse reactions. Moreover, hyperaldosterone is still not corrected by spironolactone, which cause extensive cerebrovascular damages even though blood pressure and blood potassium had been normalized.

With the development of adrenal vein sampling and adrenal ablation, the precise diagnosis and treatment of PA is possible. Selective adrenal artery ablation (AAA) was observed with significant decrease of blood aldosterone and blood pressure in patients with PA, which made it promising that primary aldosteronism with resistant hypertension could be relieved by adrenal artery ablation.

Study Name: Adrenal Artery Ablation for Primary Aldosteronism With Resistant Hypertension
Status: Completed
Conditions: Resistant Hypertension
Interventions: Procedure: Adrenal Artery Ablation
Locations: The third hospital affiliated to the Third Military Medical University, Chongqing, China, 400042
Study link: https://clinicaltrials.gov/ct2/show/NCT04345198

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©2021 Primary Aldosteronism Foundation

The Primary Aldosteronism Foundation is a registered 501(c)(3) public charity. Donations are tax deductible in the US.